SLC16A3 Back

solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

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NCBI Description of SLC16A3
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008].

Community Annotation of SLC16A3 Add / Edit SLC16A3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC16A3 is highly significantly mutated in
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SLC16A3 is significantly mutated in
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SLC16A3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC16A3