SLC12A5 Back

solute carrier family 12, (potassium-chloride transporter) member 5

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NCBI Description of SLC12A5
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.

Community Annotation of SLC12A5 Add / Edit SLC12A5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC12A5 is highly significantly mutated in
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SLC12A5 is significantly mutated in
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SLC12A5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC12A5