SLC10A2 Back

solute carrier family 10 (sodium/bile acid cotransporter family), member 2

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NCBI Description of SLC10A2
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG).

Community Annotation of SLC10A2 Add / Edit SLC10A2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC10A2 is highly significantly mutated in
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SLC10A2 is significantly mutated in
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SLC10A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC10A2