SKAP1 Back

src kinase associated phosphoprotein 1

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NCBI Description of SKAP1
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Community Annotation of SKAP1 Add / Edit SKAP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SKAP1 is highly significantly mutated in
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SKAP1 is significantly mutated in
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SKAP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SKAP1