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SIX homeobox 6

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NCBI Description of SIX6
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).

Community Annotation of SIX6 Add / Edit SIX6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SIX6 is highly significantly mutated in
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SIX6 is significantly mutated in
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SIX6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SIX6