SIVA1 Back

SIVA1, apoptosis-inducing factor

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NCBI Description of SIVA1

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SIVA1 is highly significantly mutated in
SIVA1 is significantly mutated in
SIVA1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SIVA1