SIM2 Back

single-minded homolog 2 (Drosophila)

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NCBI Description of SIM2
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes

Community Annotation of SIM2 Add / Edit SIM2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SIM2 is highly significantly mutated in
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SIM2 is significantly mutated in
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SIM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SIM2