SIL1 Back

SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SIL1
This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized.

Community Annotation of SIL1 Add / Edit SIL1: Annotations

No community annotations yet for SIL1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SIL1 is highly significantly mutated in
(none)
SIL1 is significantly mutated in
(none)
SIL1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SIL1