SIGMAR1 Back

sigma non-opioid intracellular receptor 1

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NCBI Description of SIGMAR1
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SIGMAR1 is highly significantly mutated in
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SIGMAR1 is significantly mutated in
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SIGMAR1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SIGMAR1