SIAH2 Back

seven in absentia homolog 2 (Drosophila)

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NCBI Description of SIAH2
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Community Annotation of SIAH2 Add / Edit SIAH2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SIAH2 is highly significantly mutated in
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SIAH2 is significantly mutated in
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SIAH2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SIAH2