SHMT2 Back

serine hydroxymethyltransferase 2 (mitochondrial)

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NCBI Description of SHMT2
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.

Community Annotation of SHMT2 Add / Edit SHMT2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SHMT2 is highly significantly mutated in
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SHMT2 is significantly mutated in
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SHMT2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SHMT2