SHBG Back

sex hormone-binding globulin

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NCBI Description of SHBG
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SHBG Add / Edit SHBG: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SHBG is highly significantly mutated in
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SHBG is significantly mutated in
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SHBG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SHBG