SH3RF1 Back

SH3 domain containing ring finger 1

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NCBI Description of SH3RF1
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SH3RF1 is highly significantly mutated in
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SH3RF1 is significantly mutated in
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SH3RF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SH3RF1