SH3KBP1 Back

SH3-domain kinase binding protein 1

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NCBI Description of SH3KBP1

This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SH3KBP1 is highly significantly mutated in
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SH3KBP1 is significantly mutated in
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SH3KBP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SH3KBP1