SH3GLB1 Back

SH3-domain GRB2-like endophilin B1

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NCBI Description of SH3GLB1

This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants.

Community Annotation of SH3GLB1 Add / Edit SH3GLB1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SH3GLB1 is highly significantly mutated in
SH3GLB1 is significantly mutated in
SH3GLB1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SH3GLB1