SH3BP4 Back

SH3-domain binding protein 4

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NCBI Description of SH3BP4
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.

Community Annotation of SH3BP4 Add / Edit SH3BP4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SH3BP4 is highly significantly mutated in
(none)
SH3BP4 is significantly mutated in
(none)
SH3BP4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SH3BP4