SH2D3C Back

SH2 domain containing 3C

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NCBI Description of SH2D3C

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SH2D3C is highly significantly mutated in
SH2D3C is significantly mutated in
SH2D3C is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SH2D3C