SH2D1B Back

SH2 domain containing 1B

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NCBI Description of SH2D1B

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008].

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SH2D1B is highly significantly mutated in
SH2D1B is significantly mutated in
SH2D1B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SH2D1B