SH2B3 Back

SH2B adaptor protein 3

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NCBI Description of SH2B3
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SH2B3 is highly significantly mutated in
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SH2B3 is significantly mutated in
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SH2B3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SH2B3