SH2B2 Back

SH2B adaptor protein 2

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NCBI Description of SH2B2
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SH2B2 is highly significantly mutated in
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SH2B2 is significantly mutated in
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SH2B2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SH2B2