SH2B1 Back

SH2B adaptor protein 1

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NCBI Description of SH2B1
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.

Community Annotation of SH2B1 Add / Edit SH2B1: Annotations

No community annotations yet for SH2B1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SH2B1 is highly significantly mutated in
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SH2B1 is significantly mutated in
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SH2B1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SH2B1