sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

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NCBI Description of SGCB

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.

Community Annotation of SGCB Add / Edit SGCB: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SGCB is highly significantly mutated in
SGCB is significantly mutated in
SGCB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SGCB