SFTPA2 Back

surfactant, pulmonary-associated protein A2

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NCBI Description of SFTPA2
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of SFTPA2 Add / Edit SFTPA2: Annotations

No community annotations yet for SFTPA2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SFTPA2 is highly significantly mutated in
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SFTPA2 is significantly mutated in
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SFTPA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SFTPA2