SFTPA1 Back

surfactant, pulmonary-associated protein A1

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NCBI Description of SFTPA1
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants.

Community Annotation of SFTPA1 Add / Edit SFTPA1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SFTPA1 is highly significantly mutated in
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SFTPA1 is significantly mutated in
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SFTPA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SFTPA1