SFRP5 Back

secreted frizzled-related protein 5

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NCBI Description of SFRP5
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.

Community Annotation of SFRP5 Add / Edit SFRP5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SFRP5 is highly significantly mutated in
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SFRP5 is significantly mutated in
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SFRP5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SFRP5