SFRP1 Back

secreted frizzled-related protein 1

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NCBI Description of SFRP1

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.

Community Annotation of SFRP1 Add / Edit SFRP1: Annotations

No community annotations yet for SFRP1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SFRP1 is highly significantly mutated in
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SFRP1 is significantly mutated in
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SFRP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SFRP1