SF3A3 Back

splicing factor 3a, subunit 3, 60kDa

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SF3A3
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.

Community Annotation of SF3A3 Add / Edit SF3A3: Annotations

No community annotations yet for SF3A3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SF3A3 is highly significantly mutated in
(none)
SF3A3 is significantly mutated in
(none)
SF3A3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SF3A3