NCBI Description of SETMAR
|This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.|
Community Annotation of SETMAR Add / Edit SETMAR: Annotations
No community annotations yet for SETMAR.
Click on a tumor type to see its full list of significant genes.