SETDB2 Back

SET domain, bifurcated 2

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NCBI Description of SETDB2
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SETDB2 is highly significantly mutated in
(none)
SETDB2 is significantly mutated in
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SETDB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SETDB2