SESN3 Back

sestrin 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SESN3
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

Community Annotation of SESN3 Add / Edit SESN3: Annotations

No community annotations yet for SESN3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SESN3 is highly significantly mutated in
(none)
SESN3 is significantly mutated in
(none)
SESN3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SESN3