SERPINE2 Back

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

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NCBI Description of SERPINE2

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.

Community Annotation of SERPINE2 Add / Edit SERPINE2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SERPINE2 is highly significantly mutated in
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SERPINE2 is significantly mutated in
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SERPINE2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SERPINE2