SERPINE1 Back

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

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NCBI Description of SERPINE1
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SERPINE1 is highly significantly mutated in
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SERPINE1 is significantly mutated in
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SERPINE1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SERPINE1