SERPIND1 Back

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

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NCBI Description of SERPIND1
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SERPIND1 is highly significantly mutated in
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SERPIND1 is significantly mutated in
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SERPIND1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SERPIND1