SERPINB1 Back

serpin peptidase inhibitor, clade B (ovalbumin), member 1

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NCBI Description of SERPINB1
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SERPINB1 is highly significantly mutated in
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SERPINB1 is significantly mutated in
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SERPINB1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SERPINB1