SERPINA1 Back

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

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NCBI Description of SERPINA1
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SERPINA1 is highly significantly mutated in
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SERPINA1 is significantly mutated in
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SERPINA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SERPINA1