serine active site containing 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SERAC1

The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene.

Community Annotation of SERAC1 Add / Edit SERAC1: Annotations

No community annotations yet for SERAC1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SERAC1 is highly significantly mutated in
SERAC1 is significantly mutated in
SERAC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SERAC1