Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

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NCBI Description of SEPSECS

The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SEPSECS is highly significantly mutated in
SEPSECS is significantly mutated in
SEPSECS is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SEPSECS