semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

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NCBI Description of SEMA7A

The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SEMA7A is highly significantly mutated in
SEMA7A is significantly mutated in
SEMA7A is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SEMA7A