SEC61A1 Back

Sec61 alpha 1 subunit (S. cerevisiae)

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NCBI Description of SEC61A1
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SEC61A1 is highly significantly mutated in
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SEC61A1 is significantly mutated in
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SEC61A1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SEC61A1