scribbled homolog (Drosophila)

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NCBI Description of SCRIB

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Community Annotation of SCRIB Add / Edit SCRIB: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SCRIB is highly significantly mutated in
SCRIB is significantly mutated in
SCRIB is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SCRIB