SCO2 Back

SCO cytochrome oxidase deficient homolog 2 (yeast)

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NCBI Description of SCO2
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy.

Community Annotation of SCO2 Add / Edit SCO2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCO2 is highly significantly mutated in
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SCO2 is significantly mutated in
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SCO2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SCO2