SCN9A Back

sodium channel, voltage-gated, type IX, alpha subunit

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SCN9A
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of SCN9A Add / Edit SCN9A: Annotations

No community annotations yet for SCN9A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCN9A is highly significantly mutated in
(none)
SCN9A is significantly mutated in
(none)
SCN9A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SCN9A