SCN9A Back

sodium channel, voltage-gated, type IX, alpha subunit

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NCBI Description of SCN9A

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SCN9A is highly significantly mutated in
SCN9A is significantly mutated in
SCN9A is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SCN9A