SCN4B Back

sodium channel, voltage-gated, type IV, beta

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NCBI Description of SCN4B
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.

Community Annotation of SCN4B Add / Edit SCN4B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCN4B is highly significantly mutated in
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SCN4B is significantly mutated in
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SCN4B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SCN4B