SCN3A Back

sodium channel, voltage-gated, type III, alpha subunit

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NCBI Description of SCN3A
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCN3A is highly significantly mutated in
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SCN3A is significantly mutated in
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SCN3A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SCN3A