SCN2A Back

sodium channel, voltage-gated, type II, alpha subunit

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SCN2A

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Community Annotation of SCN2A Add / Edit SCN2A: Annotations

No community annotations yet for SCN2A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCN2A is highly significantly mutated in
(none)
SCN2A is significantly mutated in
(none)
SCN2A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SCN2A