SCN11A Back

sodium channel, voltage-gated, type XI, alpha subunit

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SCN11A

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004].

Community Annotation of SCN11A Add / Edit SCN11A: Annotations

No community annotations yet for SCN11A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCN11A is highly significantly mutated in
(none)
SCN11A is significantly mutated in
(none)
SCN11A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SCN11A