SCAP Back

SREBF chaperone

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NCBI Description of SCAP
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SCAP is highly significantly mutated in
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SCAP is significantly mutated in
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SCAP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SCAP