S1PR1 Back

sphingosine-1-phosphate receptor 1

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NCBI Description of S1PR1

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


S1PR1 is highly significantly mutated in
S1PR1 is significantly mutated in
S1PR1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for S1PR1