RUVBL2 Back

RuvB-like 2 (E. coli)

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NCBI Description of RUVBL2
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RUVBL2 is highly significantly mutated in
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RUVBL2 is significantly mutated in
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RUVBL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RUVBL2