RUNX1T1 Back

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

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NCBI Description of RUNX1T1
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RUNX1T1 is highly significantly mutated in
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RUNX1T1 is significantly mutated in
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RUNX1T1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RUNX1T1